Cetrimonium chloride
A positively charged conditioner with a 16-carbon tail.
How common
403 of 14,784 products with a full ingredient list in Open Beauty Facts; No. 113 of all the names found on their labels.
What it is
A “quat” (quaternary ammonium salt): hexadecyltrimethylammonium chloride, a positively charged head on a 16-carbon tail.
2 sourcesHide
hexadecyltrimethylammonium chloride (CTAC)
[1] Study · 2026 · open sourceC 16 -alkyltrimethylammonium chloride Cetrimonium chloride
[2] EU law · 2026 · open source
Why it is in products
To condition hair and stop static. Agents like it are the backbone of a conditioner.
2 sourcesHide
used in cosmetics mainly as surfactant-cleansing agents, hair-conditioning agents, and antistatic agents
[3] US Cosmetic Ingredient Review expert panel · 2012 · open sourceCationic surfactants: Cetyltrimethylammonium chloride, behentrimonium or propyltrimonium, stearamidopropyl dimethylamine. They are considered the backbone of a conditioner
[4] Study · 2015 · open source
What it does
Makes combing easier: in one lab study of conditioner gels made with it, combing force fell by 65 to 88%.
Some evidencehairSourceHide
At a CTAC/CA system of ratio 2:10, there is a 65% reduction in combing force and a 88% reduction in combing force in the CTAC/CA system of ratio 6:10.
[5] Study · 2020 · open sourceIn a 2026 lab comparison, the longer-chain behentrimonium salts conditioned better than it.
Some evidencehairSourceHide
BTMC and BTMS were superior against CTAC and STAC due to their longer carbon chain length.
[1] Study · 2026 · open source
Downsides and safety
Like other quats it can irritate if a product is badly made: the US panel’s verdict is safe when formulated not to irritate.
Well establishedSourceHide
These ingredients were determined to be safe in the present practices of use and concentration when formulated to be nonirritating.
[3] US Cosmetic Ingredient Review expert panel · 2012 · open source
Where it works
On the hair’s surface, drawn by the hair’s negative charge.
Well establishedSourceHide
The negative charge of the hair is attracted to the positively charged conditioner molecules[4] Study · 2015 · open source
Rules
European Union
Limited by EU law (Annex III, entry 286), together with steartrimonium chloride: at most 2.5% in rinse-off hair products, 1.0% in leave-on hair products and 0.5% in leave-on face products.
3 sourcesHide
(a) Rinse-off hair products (a) 2,5 % for the individual concentrations or the sum of the individual concentrations of cetrimonium chloride and steartrimonium chloride
[2] EU law · 2026 · open source(b) Leave-on hair products (b) 1,0 % for the individual concentrations or the sum of the individual concentrations of cetrimonium chloride and steartrimonium chloride
[2] EU law · 2026 · open source(c) Leave-on face products (c) 0,5 % for the individual concentrations or the sum of the individual concentrations of cetrimonium chloride and steartrimonium chloride
[2] EU law · 2026 · open sourceUsed as a preservative, it is allowed only up to 0.1% (Annex V, entry 44).
SourceHide
0,1 % cetrimonium bromide, 57-09-0, 200-311-3, cetrimonium chloride ( 16 )
[2] EU law · 2026 · open source
United States
Not on the FDA’s list of prohibited or restricted cosmetic ingredients. In the US, cosmetics and their ingredients (other than colour additives) don’t need FDA approval before sale.
SourceHide
Under U.S. law, cosmetic products and ingredients, other than color additives, do not need FDA approval before they go on the market
[6] US Food and Drug Administration · open sourceWe searched the FDA’s list of prohibited and restricted cosmetic ingredients: no entry.open the list
Sources
- Electrokinetic analysis reveals common conditioner ingredient interactions with human hair Tham HP et al., International journal of cosmetic science, 2026StudyAuthors include staff of Ashland and Anton Paar (with A*STAR)
- Regulation (EC) No 1223/2009 on cosmetic products, consolidated text of 18 May 2026 Publications Office of the European Union (EUR-Lex/Cellar), 2026EU law
- Safety assessment of trimoniums as used in cosmetics International journal of toxicology, 2012US Cosmetic Ingredient Review expert panel
- Shampoo and Conditioners: What a Dermatologist Should Know? Indian Journal of Dermatology, 2015Study
- Microstructure design of CTAC:FA and BTAC:FA lamellar gels for optimized rheological performance utilizing automated formulation platform Davies AR et al., International journal of cosmetic science, 2020Study
- Prohibited & Restricted Ingredients in Cosmetics | FDA US Food and Drug Administration
Checked against these sources on 4 November 2026. Spot a mistake? Tell us.